Wolfram, Vega, and Thiele

Wolfram syndrome.

Wolfram syndrome is a rare neurodegenerative and genetic disorder, which should be suspected in patients with young onset non-immune insulin dependent diabetes mellitus and optic atrophy. Patients are most likely to develop diabetes insipidus, deafness, urinary tract, and neurological abnormalities. 60% of the people with Wolfram syndrome die at age 35, usually due to central respiratory center...

Bivariate Blending Thiele-Werner’s Osculatory Rational Interpolation

OPINION Wolfram syndrome 1 and Wolfram syndrome 2: clinical implications for pediatricians

Purpose of review Wolfram syndrome 1 (WS1) is an autosomal recessive disorder characterized by diabetes insipidus, diabetes mellitus, optic atrophy, and deafness (DI DM OA D syndrome) associated with other variable clinical manifestations. The causative gene for WS1 (WFS1) encoding wolframin maps to chromosome 4p16.1. Wolframin has an important function in maintaining the homeostasis of the end...

Interactive Conjecturing with Vega

16-de Vega-Chap16

One of the most important applications of grounded cognition theories is to science and mathematics education, where the primary goal is to foster knowledge and skills that are widely transportable to new situations. This presents a challenge to those grounded cognition theories that tightly tie knowledge to the specifics of a single situation. In this chapter, we develop a theory learning that...